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Health and Nutrition

Environmental Health Cohorts Maintenance and Infrastructure (R24)

The purpose of this Funding Opportunity Announcement (FOA) is to solicit grant applications that propose to: (1) support the maintenance of existing Environmental Epidemiology Cohorts (EECs) and to (2) enrich research infrastructure to improve scientific activities and resource sharing with the broader scientific communities. The ultimate goal is to maintain and maximize NIEHS cohort investments within the environmental epidemiology community by supporting the infrastructure needed to prepare for future research opportunities and to promote broader scientific collaborations.

Engineering Next-Generation Human Nervous System Microphysiological Systems (R21)

This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) with improved fidelity to complex human brain, spinal, peripheral nervous system and/or sensory end organ circuit physiology in vivo, which will ultimately facilitate analysis of higher order functional deficits relevant to complex nervous system disorders.

Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R21)

This funding opportunity announcement (FOA) encourages a wide range of collaborative research projects related to patient safety in the context of perinatal, neonatal and pediatric care both in routine hospital settings and in the intensive care units. The FOA welcomes applications related to (but not limited to): the epidemiology of various domains of medical errors and consequent patient harm; assessing the factors at various levels that contribute to such errors; and intervention strategies at individual, systems, and institutional levels to help reduce and eliminate medical errors.

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (UH2/UH3)

The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN receive funding for activities to be conducted in their own laboratories and the opportunity to collaborate with NIH-funded consultants and contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis under Good Manufacturing Practices (GMP), and Phase I clinical testing.

Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03)

The purpose of this funding opportunity is to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more research of all types. It is hoped that this research will inform subsequent R01 applications, and ultimately translate into improved outcomes for children with MODS, both in terms of prevention and treatment.

High Throughput Screening (HTS) to Discover Chemical Probes (R01)

This Funding Opportunity Announcement (FOA) encourages investigators to form collaborations with an established academic, nonprofit, or commercial high throughput screening (HTS) facility that has the requisite expertise and experience to implement HTS-ready assays for the discovery and development of small molecule chemical probes.

Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)

This Funding Opportunity Announcement (FOA) encourages Exploratory/Developmental Research Grant (R21) applications from institutions/ organizations that propose research relevant to the basic understanding and development of therapeutic interventions for currently screened conditions and high priority genetic conditions for which screening could be possible in the near future.In this FOA, a high priority condition is one for which the development of an efficacious therapy would make the condition amenable to newborn screening.

Pharmacogenetics, Pharmacoepigenetics and Personalized Medicine in Children (R01)

The purpose of this funding opportunity announcement (FOA) is to encourage pharmacogenetic and epigenetic studies and improved phenotypingin childrens pharmacotherapy that will allow individualization of treatment in children.

Mentored Patient-Oriented Research Career Development Award (Parent K23)

The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research. Individuals with a clinical degree who are interested in further career development in biomedical research other than patient-oriented research should refer to the Mentored Clinical Scientist Career Development (Parent K08) Award.

Discovery of in vivo Chemical Probes (R01)

This Funding Opportunity Announcement (FOA) intends to support investigators who have interest and capability to join efforts for the discovery of in vivo chemical probes. It is expected that applicants will have in hand the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.