This report is the first to be issued by a federal agency that comprehensively reviews the public health issue of electronic cigarettes and their impact on young people. Using evidence gathered from studies that included young adolescents, adolescents, and young adults, this report confirms there is no acceptable level of nicotine when it comes to these populations and the aerosol from e-cigarettes is not harmless. The report website also offers tools for parents and a public service announcement.