Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)

The purpose of this FOA is to ?c?r?e?a?t?e? ?a? ?c?l?i?n?i?c?a?l? consortium to recruit a cohort o?f early pubertal youth at risk for developing type 2 diabetes and study them th?r?o?ugh puberty. The ultimate goal of this undertaking will be to 1) develop more precise prediction of which individuals are truly at risk for developing you?t?h-onset T2D and identify determinants of progression from prediabetes to T2D so that, ultimately, targeted prevention approaches can be developed and tested; and 2) increase understanding ofthe physiologic drivers of youth-onset T2D to guide development of more effective strategies to achieve glycemic control and preserve beta cell function.